Consensus Reports
Reported in EPA TSCA Inventory.
Specification
1. Introduction of L-Glutamic acid
L-Glutamic acid, with the IUPAC Name of (2S)-2-Aminopentanedioic acid, is one kind of white cryst. powder. This chemical belongs to the Product Categories which include Food & Feed ADDITIVES; chiral; Glutamic acid [Glu, E]; Amino Acids and Derivatives; alpha-Amino Acids; Amino Acids; Biochemistry; for Resolution of Bases; Optical Resolution; Synthetic Organic Chemistry; Nutritional Supplements; Amino Acids; Chiral Compound; Glutamate receptor; Glutamate; fine chemicals; glutamic acid; amino acid; bio-chemical; chemicals; food additive; food additives; nutritional supplement; organic acids; pharmaceutical intermediate.
2. Properties of L-Glutamic acid
L-Glutamic acid has the following property datas: (1)Melting point: 205 °C; (2)Index of Refraction: 1.522; (3)Molar Refractivity: 31.83 cm3; (4)Molar Volume: 104.3 cm3; (5)Surface Tension: 69.2 dyne/cm; (6)Density: 1.409 g/cm3; (7)Flash Point: 155.7 °C; (8)Enthalpy of Vaporization: 63.39 kJ/mol; (9)Boiling Point: 333.8 °C at 760 mmHg; (10)Vapour Pressure: 2.55E-05 mmHg at 25 °C; (11)storage temp.: Store at RT.; (12)solubility: 1 M HCl: 100 mg/mL; (13)Water Solubility: 7.5 g/L (20 °C).
3. Structure Descriptors of L-Glutamic acid
You could convert the following datas into the molecular structure:
InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKey: InChIKey=WHUUTDBJXJRKMK-VKHMYHEASA-N
Smiles: [C@H](CCC(=O)O)(C(=O)O)N
4. Toxicity of L-Glutamic acid
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | intravenous | 117mg/kg (117mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | American Journal of the Medical Sciences. Vol. 214, Pg. 281, 1947. |
| human | TDLo | oral | 71mg/kg (71mg/kg) | BEHAVIORAL: HEADACHE | Science. Vol. 163, Pg. 826, 1969. |
| rabbit | LD50 | oral | > 2300mg/kg (2300mg/kg) | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 42, 1970. | |
| rat | LD50 | oral | > 30gm/kg (30000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 42, 1970. |
5. Safety Information of L-Glutamic acid
Hazard Codes of L-Glutamic acid (CAS NO.56-86-0):
Xi Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 2
RTECS: LZ9700000
F: 10
Human systemic effects by ingestion and intravenous routes: headache and nausea or vomiting. When heated to decomposition it emits toxic fumes of NOx.
6. Production of L-Glutamic acid
L-Glutamic acid can be obtained directly from fermentation of carbohydrates with Micrococcus glutarnicus or Brevihacterium divaricatum.